Granulation

Granulation Technology

Wet granulation: the Euronovis method for the nutraceutical sector

Euronovis offers a complete and innovative wet granulation service for the nutraceutical sector, designed to meet the production needs of Life Science contract manufacturers looking for a specialized partner in granulation services.

From the preliminary study to the production of industrial batches, the granulation process offered by Euronovis is meticulously controlled in every aspect to ensure the reproducibility of nutraceutical granules based on specific characteristics such as particle size, moisture content, flowability, and bulk density.

Our granules, produced using High Shear Mixers and Fluid Bed Dryer technology, can be used directly or undergo further processing for the preparation of other pharmaceutical forms.

Granulation process

The complete wet granulation process:
from formulation development to finished product

Euronovis supports customers from the earliest stages of product development and optimization.
Depending on the properties of the starting powder, appropriate binding agents may be added to ensure the correct granule formation by promoting interparticle bonding (wet granulation). The subsequent drying phase consolidates the final product’s characteristics, which can then be calibrated according to the client’s specific needs.

Granulation is a widely used process in the pharmaceutical, nutraceutical, and food industries to increase powder particle size, improving flowability and compaction properties. Thanks to its strong pharmaceutical expertise, Euronovis assists clients from the initial product development stages, offering tailor-made wet granulation processes. Based on the characteristics of the starting powder, suitable binding agents are added to ensure proper granule formation by promoting interparticle bonding. The drying phase then consolidates the product’s characteristics, which can be further calibrated to meet specific requirements.

Advanced technologies for perfect granulation

The new Euronovis granulation department is equipped with NICOMIX 75-200 High Shear Mixer (production capacity: 50 to 100 kg) and a NICOBED 120 Fluid Bed Dryer (production capacity: 50 to 100 kg). Depending on the type of products being processed, a single piece of equipment may be sufficient, or a combination of a High Shear Mixer and Fluid Bed Dryer may be required. These solutions ensure excellent production flexibility and allow us to meet any request related to wet granulation.

Model Type Min capacity Max capacity
HSM Nicomix 75-200 High Shear Mixer 50 kg 100 kg
FBD Nicobed 8 Fluid Bed Dryer 1 kg 5 kg
FBD Nicobed 120 Fluid Bed Dryer 50 kg 100 kg

Quality control with PLC-PC system

Our production process is monitored through advanced PLC-PC systems with software compliant with CFR 21 Part 11, ensuring maximum safety and traceability at every stage of production.

Cleaning and Safety in Granulation Processes

Our facilities use a fully automated WIP (Wash-in-Place) cleaning system, speeding up cleaning operations and guaranteeing the hygiene standards required. This system improves process safety and minimizes the risk of cross-contamination.

Our Research & Development (R&D) department is dedicated to the physical characterization of granules, using advanced tools such as:

  • Particle size analyzer – Measures particle size distribution
  • Moisture balance – Determines moisture content
  • Bulk density and flowability measurement system – Analyzes the physical properties of granules

During the research and development phase, we use the same type of equipment on a small scale (2-3 kg) as we do in industrial production, allowing for optimized scale-up and minimizing technology transfer errors.

Why choose Euronovis for your wet granulation?

Euronovis is a highly specialized contract manufacturing company. We position ourselves as a reliable partner for companies seeking expertise, innovation, production flexibility, and on-time delivery for their wet granulation processes. Our experience, technical background, pharmaceutical standards, cutting-edge technologies, and customized approach make us the ideal partner for third-party granulation.

Want more information?

The fastest and most direct way to get in touch with the Euronovis team is to fill out the form on the side. Let us know what you need, and the right specialist will contact you as soon as possible.