Pelletization

Pelletization Technology

The Euronovis method for nutraceutical pelletization

Euronovis offers advanced solutions for the production of nutraceutical pellets using cutting-edge technologies that ensure uniformity, size control, and precise dosage of the active ingredient. Thanks to our highly specialized processes, including powder layering and extrusion/spheronization, we optimize production times and costs while ensuring maximum flexibility and safety. Our team guides each client toward the most suitable solution, tailoring production to specific requirements.

Nutraceutical pellets

Customized release for dietary supplements

Nutraceutical pellets are small solid units with a spherical or pseudo-spherical shape, typically ranging from 500 to 1,500 microns in size. These are classified as multiple-unit dosage forms and can be easily incorporated into sachets, hard capsules, or compressed tablets. Pellets offer numerous advantages over other solid dosage forms, particularly in controlled release of active ingredients, making them ideal for use in dietary supplements.

Advantages of pellets over other solid dosage forms

Nutraceutical pellets stand out for the following advantages:

  • Improved Safety and Efficacy: Due to their structure, pellets provide greater reproducibility in the release of active ingredients, reducing variability influenced by gastrointestinal transit times and digestive phases.
  • Controlled Release: The pellet form enables precise and controlled release of the active ingredient, which can be tailored to optimize absorption in the most suitable areas of the gastrointestinal tract.
  • Better Absorption Profile: Pellet technology minimizes the risk of overdosing or underdosing, ensuring greater consistency in the final product’s efficacy.

Pelletization process

Production of nutraceutical pellets:
Advanced technologies for customized solutions

With extensive pharmaceutical expertise and nutraceutical industry know-how, Euronovis provides contract manufacturing solutions for nutraceutical supplement producers. By utilizing two pelletization technologies—powder layering (in a coating pan or fluid bed) and extrusion/spheronization—we meet diverse client needs, ensuring optimal results in pellet uniformity, size control, dosage precision, and production efficiency.

Powder layering is a technique that gradually applies active powder layers onto inert starter cores. This process occurs in a coating pan or fluid bed, where powders are layered to create uniformly sized and evenly distributed pellets. This method offers:

  • Controlled Release: Pellet formation enables precise and gradual release of active ingredients, optimizing absorption.
  • Accurate Size Control: The layering process ensures consistent pellet size, enhancing product quality and effectiveness.
  • Flexible Production: Ideal for small to medium-scale production, powder layering allows customization based on client needs.

The extrusion/spheronization process is another advanced technique used to produce solid and uniform pellets. During extrusion, an active powder mixture is forced through a die to form a cylindrical shape, which is then processed in the spheronization phase to create smooth, spherical pellets. The advantages of this technique include:

  • Enhanced Uniformity: The combination of extrusion and spheronization ensures precise and homogeneous pellet size, essential for product stability and efficacy.
  • Dosage Control: Extrusion guarantees even distribution of the active ingredient within each pellet, allowing for accurate dosage control.
  • Scalability and Productivity: This method is particularly suitable for large-scale production, thanks to its efficiency in optimizing production times and reducing overall costs.

Depending on the client’s specific requirements and the type of product being developed, Euronovis selects the most suitable technology between powder layering and extrusion/spheronization. Our expertise enables us to:

  • Customize production according to the active ingredient type and desired release profile.
  • Optimize production costs and time by selecting the most efficient technology for each case.
  • Ensure a high-quality final product with perfectly uniform pellets and precise, reproducible dosing.

To achieve the best results at every stage of production, we use cutting-edge equipment, including:

  • Nicomac Coating Pans and Fluid Beds: Ideal for powder layering, these technologies enable precise and uniform powder stratification, ensuring high-quality, flexible production.
  • Caleva Extruders and Spheronizers: These systems produce pellets with optimal size, appearance, and homogeneity by combining extrusion and spheronization.

Our innovative pelletization processes provide clients with numerous benefits:

  • Uniform pellet size and controlled dimensions, improving final product efficacy.
  • Precise active ingredient dosing, ensuring greater accuracy and reliability.
  • Optimized production costs and time, leveraging efficient, advanced technologies.
  • Fully customized production, offering highly flexible solutions tailored to client needs.

Euronovis is the ideal partner for companies seeking advanced solutions for nutraceutical pellet production. We support the nutraceutical and pharmaceutical industries with the latest technologies, ensuring quality, reliability, and exceptional performance throughout the entire production process.

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